Potassium Hydroxide → 2-(2,2,2-Trifluoroethoxy)benzoic acid
反応式
[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8].[OH-].[K+]>O>[F:1][C:2]([F:15])([F:16])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]参加物
4
実験手順
Methyl 2-(2,2,2-trifluoroethoxy)benzoate (8 g., 34.2 mmoles) potassium hydroxide (3.3 g., 350 mmoles), water (50 ml.) and alcohol (25 ml.) are heated together under reflux for 1.5 hours, and distilled until ca. 25 ml. of distillate is removed. The cooled residue is acidified (pH 3) and the resulting white solid is collected and recrystallized (aqueous alcohol) to give fluffy white solid, m.p. 85°-86.5° C.
後処理
- temperatureunder reflux for 1.5 hours
- distillationdistilled until ca. 25 ml
- customof distillate is removed
- customthe resulting white solid is collected
- customrecrystallized (aqueous alcohol)
- customto give fluffy white solid, m.p. 85°-86.5° C.
出典と根拠
- ORDレコード
- ord-7a78e4d087714dbd9e54ca28584bf433
- 出典データセット
- uspto-grants-1976_12
- 特許番号
- US03996280
反応ノート
読み込み中…