Ethanol → 1-(2,2,2-Trifluoroethoxy)-2-Naphthoic Acid
反応式
[F:1][C:2]([F:20])([F:19])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:15]([O:17]C)=[O:16].[OH-].[K+].C(O)C>O>[F:1][C:2]([F:19])([F:20])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:15]([OH:17])=[O:16]参加物
5
実験手順
A mixture of 10 g. (35 mmoles) of methyl 1-(2,2,2-trifluoroethoxy)-2-naphthoate, 2.9 g., (42 mmoles) of potassium hydroxide, 50 ml. of ethanol and 40 ml. of water is refluxed for one hour, chilled and acidified. The fluffy precipitate is collected, water washed, and air-dried. It is purified by recrystallization first from chloroform and then from aqueous alcohol, m.p. 171.5°-172° C.
後処理
- additionA mixture of 10 g
- temperaturechilled
- customThe fluffy precipitate is collected
- washwater washed
- customair-dried
- customIt is purified by recrystallization first from chloroform
出典と根拠
- ORDレコード
- ord-7aeb48dd48134ebea64d7748f1e929a7
- 出典データセット
- uspto-grants-1976_12
- 特許番号
- US03996280
反応ノート
読み込み中…