4-(5-Cyclopropyl-1,2-oxazol-3-yl)pyridine → HCID 68142299、化合物
反応式
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=3)[CH:5]=2)[CH2:3][CH2:2]1.[H][H]>[Pt]=O.C(O)C>[NH2:7][C:6]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)=[CH:5][C:4]([CH:1]1[CH2:2][CH2:3]1)=[O:8]参加物
5
実験手順
A solution of 3 g. of 4-(5-cyclopropyl-3-isoxazolyl)pyridine in 50 ml. of ethanol is treated with 0.5 g. of platinum oxide and the mixture is treated with hydrogen on a Parr apparatus at 44 psi for 5 hours at 25° C. The mixture is filtered and the filtrate is evaporated to dryness under reduced pressure to give a semi-solid residue which is recrystallized from ethyl acetate to give light tan crystals, melting point 159°-166° C.
後処理
- filtrationThe mixture is filtered
- customthe filtrate is evaporated to dryness under reduced pressure
- customto give a semi-solid residue which
- customis recrystallized from ethyl acetate
- customto give light tan crystals, melting point 159°-166° C.
出典と根拠
- ORDレコード
- ord-b983dbe6bf914c82a230c439a5bf25b6
- 出典データセット
- uspto-grants-1976_12
- 特許番号
- US03997530
反応ノート
読み込み中…