Hydrochloric Acid → 2,1-Benzothiazol-7-ol
反応式
C[O:2][C:3]1[C:11]2[C:7](=[CH:8][S:9][N:10]=2)[CH:6]=[CH:5][CH:4]=1.Cl.Cl.COC1C2C(=CSN=2)C=CC=1.B(Br)(Br)Br>CCOCC.C(Cl)Cl>[OH:2][C:3]1[C:11]2[C:7](=[CH:8][S:9][N:10]=2)[CH:6]=[CH:5][CH:4]=1参加物
7
実験手順
7-Methoxy-2,1-benzisothiazole was dissolved in ether and converted to the hydrochloride using dry hydrogen chloride gas. The 7-methoxy-2,1-benzisothiazole hydrochloride (6.0 g.) was refluxed 22 hours in a solution of 16 g. boron tribromide and 160 ml. methylene chloride to give 3.78 g. pure, yellow, crystalline 7-hydroxy-2,1-benzisothiazole, mp. 99°-100.5° after recrystallization from hexane. This structure was confirmed by nmr.
後処理
- custompure, yellow, crystalline 7-hydroxy-2,1-benzisothiazole, mp. 99°-100.5° after recrystallization from hexane
出典と根拠
- ORDレコード
- ord-29bb1d2c20524980ad92a437f64b1594
- 出典データセット
- uspto-grants-1976_12
- 特許番号
- US03997548
反応ノート
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