Hydrochloric Acid → 6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid hydrochloride
反応式
C([O:3][C:4]([C:6]1(C(OCC)=O)[CH2:14][C:13]2[N:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:7]1)=[O:5])C.[ClH:20]>>[ClH:20].[N:12]1[C:13]2[CH2:14][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][C:8]=2[CH:9]=[CH:10][CH:11]=1参加物
3
実験手順
5,7-Dihydro-[1]pyrindine-6,6-dicarboxylic acid diethyl ester (0.953 g, 3.62 mmol) is taken into concentrated hydrochloric acid, heated to reflux for 4 hours and evaporated to afford 6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid hydrochloride. δc (DMSO-d6) 33.9 (t), 34.5 (t) 41.2 (d), 124.8 (d), 140.1 (d), 140.8 (d), 141.2 (s), 158.4 (s), 175.2 (s).
後処理
- temperatureheated
- temperatureto reflux for 4 hours
- customevaporated
出典と根拠
- ORDレコード
- ord-d044b15e3bc640e38db51ed53b337563
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745462B2
反応ノート
読み込み中…