Potassium → N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

HRID 1973448

反応式

HRID 1973448 の反応式
[CH:1]12[C:15](=[O:16])[NH:14][C:13](=[O:17])[CH:2]1[C:3]1[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]2=3)[CH:6]=[CH:5][CH:4]=1.[K].S(C1C=CC(C)=CC=1)(O)(=O)=O.O[CH2:31][CH2:32][N:33]1[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=[C:34]1[CH3:41]>O>[CH3:41][C:34]1[N:33]([CH2:32][CH2:31][N:14]2[C:13](=[O:17])[CH:2]3[C:3]4[C:12]5[C:7](=[CH:8][CH:9]=[CH:10][C:11]=5[CH:1]3[C:15]2=[O:16])[CH:6]=[CH:5][CH:4]=4)[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=1

参加物

5

反応物 3

HCID 5462222PotassiumHCID 21491653Acenaphthene-1,2-dicarboximideHCID 867342581-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole tosylate

生成物 1

HCID 21491671N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Acenaphthene-1,2-dicarboximide is converted to the potassium salt and reacted with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole tosylate according to the procedure described in Example 13. The crude reaction mixture is cooled and diluted with water, and then extracted with toluene. The solvent is evaporated from the toluene extract and the residue recrystallized from ethanol to give N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide melting at about 183°-185° C.

後処理

  1. customThe crude reaction mixture
  2. temperatureis cooled
  3. extractionextracted with toluene
  4. customThe solvent is evaporated from the toluene
  5. extractionextract
  6. customthe residue recrystallized from ethanol

出典と根拠

ORDレコード
ord-89f21b68d4a7411f94b4a050c9f0a229
出典データセット
uspto-grants-1976_12
特許番号
US03997572

関連ノート

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