1,2,3,6-Tetrahydrophthalimide → N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-1,2,3,6-tetrahydrophthalimide

HRID 1973449

反応式

HRID 1973449 の反応式
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[CH:3]2[CH2:7][CH:8]=[CH:9][CH2:10][CH:2]12.[K].S(C1C=CC(C)=CC=1)(O)(=O)=O.O[CH2:25][CH2:26][N:27]1[C:31]([N+:32]([O-:34])=[O:33])=[CH:30][N:29]=[C:28]1[CH3:35]>>[CH3:35][C:28]1[N:27]([CH2:26][CH2:25][N:5]2[C:1](=[O:11])[CH:2]3[CH2:10][CH:9]=[CH:8][CH2:7][CH:3]3[C:4]2=[O:6])[C:31]([N+:32]([O-:34])=[O:33])=[CH:30][N:29]=1

参加物

4

反応物 3

HCID 68081,2,3,6-TetrahydrophthalimideHCID 5462222PotassiumHCID 867342581-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole tosylate

生成物 1

HCID 21491658N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-1,2,3,6-tetrahydrophthalimide

実験手順

1,2,3,6-Tetrahydrophthalimide is converted to the potassium salt and reacted with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole tosylate according to the procedure described in Example 13. The crude reaction mixture obtained is concentrated and the concentrate distributed between water and toluene. The toluene layer is separated and the solvent is evaporated to leave a residue which is recrystallized from 2-propanol, affording N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-1,2,3,6-tetrahydrophthalimide melting at about 118°-123° C.

後処理

  1. customThe crude reaction mixture
  2. customobtained
  3. concentrationis concentrated
  4. customThe toluene layer is separated
  5. customthe solvent is evaporated
  6. customto leave a residue which
  7. customis recrystallized from 2-propanol

出典と根拠

ORDレコード
ord-90b718b0ea0140c8a9bcde1fb2cba8b1
出典データセット
uspto-grants-1976_12
特許番号
US03997572

関連ノート

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