4-Amidinobenzamide Hydrochloride → HCID 13980725、化合物

HRID 1973586ノート

反応式

HRID 1973586 の反応式
Cl.[C:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=O)=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH2:14]([C:20](=[CH:23]OCC)[CH:21]=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].C[O-].[Na+].C(C1C=CN=C(C2C=CC(C(N)=O)=CC=2)N=1)CCCCC>CCOCC.CO>[CH2:14]([C:20]1[CH:21]=[N:3][C:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]#[N:11])=[CH:7][CH:6]=2)=[N:4][CH:23]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

7

反応物 4

HCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 541836714-(4-n-Hexylpyrimid-2-yl)benzoic acid amideHCID 542364922-n-Hexyl-3-ethoxy-acrolein

生成物 1

HCID 13980725HCID 13980725、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

0.082 mol. of 4-amidino-benzoic acid amide hydrochloride, suspended in a solution of 0.082 mol. 2-n-hexyl-3-ethoxy-acrolein and 0.14 mol. of sodium methylate in 150 ml. of methanol, are stirred overnight under an atmosphere of nitrogen at room temperature. The precipitate obtained by dilution of the mixture with 3 liters of ether is removed by filtration, washed with water until neutral and dried at 40° C. in a vacuum drying cupboard, whereby there are obtained 17.9 g. of 4-(4-n-hexylpyrimid-2-yl)-benzoic acid amide; melting point 231.6°-233.0° C.

後処理

  1. customis removed by filtration
  2. washwashed with water until neutral and
  3. customdried at 40° C. in a vacuum
  4. customdrying cupboard, whereby there
  5. customare obtained 17.9 g

出典と根拠

ORDレコード
ord-e370640e25d64975bb8354ff9dc3b927
出典データセット
uspto-grants-1976_12
特許番号
US03997536

反応ノート

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