化工社化工社 化学情報印刷レポート · 研究参考用
Benzaldehyde → (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | (S)-3-(tert-Butylamino)propane-1,2-diol | HCID 2733671 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine | HCID 86734277 | — |
反応手順
22 g of (S)-1-tert.butylamino-2,3-dihydroxypropane, 20.7 g of benzaldehyde and 46 cc of benzene are heated at reflux in a water separator for 16 hours. The benzene and benzaldehyde are removed by distillation and the residue is distilled in a high vacuum. (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine is obtained as yellowish oil (B.P. 110°-125° at 0.01 mm of Hg); [α]20546 = 17.8° (c = 1.99; chloroform).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03998835 |
| 出典データセット | uspto-grants-1976_12 |
| ORD ID | ord-87237c1e6f21415095e22b72680f230e |
| 出典メモ | uspto-grants-1976_12 |