Benzoyl chloride, 3,4-dichloro- → Ethyl 5-(3,4-dichlorobenzoyl)-1,4-dimethylpyrrole-2-acetate
反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]1[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].[Cl:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[Cl:24])[C:18](Cl)=[O:19]>C1(C)C(C)=CC=CC=1>[Cl:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[Cl:24])[C:18]([C:6]1[N:2]([CH3:1])[C:3]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:5]=1[CH3:7])=[O:19]参加物
4
実験手順
A solution of 3.6 g of ethyl 1,4-dimethylpyrrole-2-acetate and 8.3 g of 3,4-dichlorobenzoyl chloride in 20 ml of xylene is refluxed for 40 min and then chilled. The separated solid is collected by filtration and dried to give 5.6 g (80%) of ethyl 5-(3,4-dichlorobenzoyl)-1,4-dimethylpyrrole-2-acetate as white crystals, m.p. 92°-93.5° C.