21-Methyl-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

HRID 1973715ノート

反応式

HRID 1973715 の反応式
[CH3:1][CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1>O.Cl.Cl.Cl[Ir](Cl)(Cl)Cl>[OH:24][C@@H:13]1[CH2:14][CH2:15][C@@:16]2([CH3:17])[C@@H:11]([CH2:10][CH2:9][C@@H:8]3[C@@H:18]2[C:19](=[O:23])[CH2:20][C@@:21]2([CH3:22])[C@H:7]3[CH2:6][CH2:5][C@@H:4]2[C:3](=[O:25])[CH2:2][CH3:1])[CH2:12]1

参加物

3

反応物 1

HCID 13171057521-Methyl-5alpha-pregnane-3,11,20-trione

生成物 1

HCID 867342873alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

試薬・触媒・溶媒 1

HCID 16211483Tetrachloroiridium--hydrogen chloride--water (1/2/1)触媒

実験手順

21-Methyl-5α-pregnane-3,11,20-trione (0.4 g.) was added to "stock" chloroiridic acid solution (75 ml.) and the resulting mixture was refluxed for 2 hr. The solution was then cooled and partitioned between water and ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried (Na2SO4) and evaporated.

後処理

  1. temperaturethe resulting mixture was refluxed for 2 hr
  2. temperatureThe solution was then cooled
  3. custompartitioned between water and ether
  4. washThe organic layer was washed with saturated aqueous sodium bicarbonate
  5. dry with materialdried (Na2SO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-74f27b354f7046d6a5fd64635496c2cf
出典データセット
uspto-grants-1976_12
特許番号
US03998829

反応ノート

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