Sulfuric Acid → 2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

HRID 1974326ノート

反応式

HRID 1974326 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)#[N:2].S(=O)(=O)(O)[OH:19].[OH-].[NH4+]>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)(=[O:19])[NH2:2]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 124454992-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzonitrile

生成物 1

HCID 124455002-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

実験手順

The cyano compound (from Example 7) (600 mg.) was dissolved in 8 ml. of concentrated sulfuric acid with ice cooling. After standing at room temperature for 7 hours it was poured onto ice. The cold solution was treated with an excess of ammonium hydroxide. The precipitate was collected, air dried and recrystallized from dimethylformamide and water to give 3-(2-carbamoylphenyl)-3H-1,2,3-triazolo[4,5-b]pyridine, m.p. >340° C.

後処理

  1. additionit was poured onto ice
  2. customThe precipitate was collected
  3. customair dried
  4. customrecrystallized from dimethylformamide and water

出典と根拠

ORDレコード
ord-9bf51204d5484c06a9628526e635a6d7
出典データセット
uspto-grants-1976_12
特許番号
US04000286

反応ノート

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