Imidazole → 2-Amino-6-imidazolyl-3-nitropyridine
反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1.O>CN(C)C=O>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([C:13]2[NH:12][CH:16]=[CH:15][N:14]=2)[N:3]=1参加物
5
反応条件
- 温度
- 120 °C
実験手順
In 80 ml of N,N-dimethylformamide were dissolved 4.00 g of 2-amino-6-chloro-3-nitropyridine and 15.69 g of imidazole, and the solution was stirred at 120° C. overnight. After spontaneous cooling to room temperature, 100 ml of water was added and the resulting crystals were collected by filtration. The crystals were rinsed with a small amount of water and dried under reduced pressure to provide 3.76 g of 2-amino-6-imidazolyl-3-nitropyridine. Physicochemical properties:
後処理
- temperatureAfter spontaneous cooling to room temperature
- filtrationthe resulting crystals were collected by filtration
- washThe crystals were rinsed with a small amount of water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-8083c1e4eb534a719866e28c0fed96f7
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05283244
反応ノート
読み込み中…