Imidazole → 4-Amino-2-(1-imidazolyl)-5-nitrobenzonitrile
反応式
[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>CN(C=O)C.O>[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[CH:3]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
In 5 ml of DMF were dissolved 1 g of 4-amino-2-fluoro-5-nitrobenzonitrile and 1.1 g of imidazole, and the mixture was stirred at 100° C. for 1 hour. The reaction mixture was then diluted with water and the resulting crystals were recovered by filtration to provide 1.2 g of 4-amino-2-(1-imidazolyl)-5-nitrobenzonitrile. Physicochemical properties:
後処理
- filtrationthe resulting crystals were recovered by filtration
出典と根拠
- ORDレコード
- ord-e22b3da583c34e09ab26d9a16d00bdb4
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05283244
反応ノート
読み込み中…