Hydrochloric Acid → 2-(4-Fluorophenylthio)-6-fluorobenzoic acid

HRID 1974755ノート

反応式

HRID 1974755 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[C:16]2[O:17]CC(C)(C)N=2)=[CH:4][CH:3]=1.Cl.[OH2:24]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[C:16]([OH:17])=[O:24])=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 191022272-[2-(4-Fluorophenylthio)-6-fluorophenyl]-4,4-dimethyloxazoline

生成物 1

HCID 191022242-(4-Fluorophenylthio)-6-fluorobenzoic acid

実験手順

The compound 2-[2-(4-fluorophenylthio)-6-fluorophenyl]-4,4-dimethyloxazoline (5.0 g, 15.66 mmol) is added to 310 ml of a 4.5N HCl solution in water and is refluxed overnight. The cooled reaction mixture is extracted twice with ethyl acetate. The extracts are washed with water and then brine and dried over MgSO4 to afford the subtitle compound.

後処理

  1. temperatureis refluxed overnight
  2. customThe cooled reaction mixture
  3. extractionis extracted twice with ethyl acetate
  4. washThe extracts are washed with water
  5. dry with materialbrine and dried over MgSO4

出典と根拠

ORDレコード
ord-3f64436bf89c4a4e90f95fe819ca203f
出典データセット
uspto-grants-1994_02
特許番号
US05283361

反応ノート

読み込み中…