関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Methoxy-4-nitropyridine-n-oxide | HCID 579207 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Methoxypyridin-4-amine | HCID 280891 | — |
反応手順
A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05284838 |
|---|
| 出典データセット | uspto-grants-1994_02 |
|---|
| ORD ID | ord-90187e1883424e1999df727823c3ea76 |
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| 出典メモ | uspto-grants-1994_02 |
|---|
