Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

反応式

[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 19382159HCID 19382159、化合物

生成物 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

実験手順

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

後処理

concentrationThe product is concentrated
customthe crystals are triturated with acetone
filtrationfiltered off with suction
dry with materialdried in a vacuum desiccator over P4O10

出典と根拠

ORDレコード: ord-09706ab2dac248c9b2ece0af30bd9028
出典データセット: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05284842

反応ノート

読み込み中…

参加物