Diethyl Oxalate → Thieno[2,3-b]pyrazine-2,3(1H,4H)-dione
反応式
[S:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](OC(C)(C)C)=[O:8])=[C:2]1[NH:14][C:15]([O:17]C(C)(C)C)=O.C(OCC)(=O)C(OCC)=O>C(O)(=O)C>[NH:6]1[C:7](=[O:8])[C:15](=[O:17])[NH:14][C:2]2[S:1][CH:5]=[CH:4][C:3]1=2参加物
4
実験手順
A mixture of di-t-butyl thiophene-2,3-dicarbamate (1.53 g, 4.87 mmol), diethyl oxalate (15 ml) and acetic acid (15 ml) was refluxed for 48 hours. The precipitate was filtered off, washed with water and dried to yield 0.64 g (78%) of the title compound. M.p. >340° C. 1H-NMR (DMSO-d6, δ): 6.74 (d, 1H), 7.13 (d, 1H), 12.28 (s, 1H).
後処理
- temperaturewas refluxed for 48 hours
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-641f15be9ad14c66bd62c2230aecea1a
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05284847
反応ノート
読み込み中…