HCID 19100941、化合物 → 5-Chloro-2-methyl-2,7-diazabicyclo[3.3.0]octane
反応式
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2参加物
3
実験手順
9.3 g (40 mmol) of ethyl 5-chloro-2-methyl-2,7-diazabicyclo[3.3. 0 ]octane-7-carboxylate are refluxed overnight together with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, the concentrate is taken up in 30 ml of water, and this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 ml portions of chloroform. The extracts are dried over potassium carbonate, concentrated and distilled.
後処理
- concentrationThe mixture is concentrated
- extractionextracted five times
- dry with materialThe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-c6bfc97754184e48b85de62f7e123418
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05284855
反応ノート
読み込み中…