HCID 19100959、化合物 → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1975013ノート

反応式

HRID 1975013 の反応式
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

参加物

3

反応物 1

HCID 19100959HCID 19100959、化合物

生成物 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0 ]octane-7-carboxylate together with 30 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 30 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 mi portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

後処理

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

出典と根拠

ORDレコード
ord-3b7d2e3ebd244f23b5466b3961aa741e
出典データセット
uspto-grants-1994_02
特許番号
US05284855

反応ノート

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