Potassium Carbonate → 2,9-Diazatricyclo[5.3.0.0,2,5]decane

HRID 1975014ノート

反応式

HRID 1975014 の反応式
[N:1]12[CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>O>[N:1]12[CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 54190177Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

生成物 1

HCID 162289032,9-Diazatricyclo[5.3.0.0,2,5]decane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

13.7 g (65.1 mmol) of ethyl 1,4-diazatricyclo[6.2.0.02,6 ]decane-4-carboxylate together with 42 g of Ba(OH)2 ×8H2O are refluxed overnight in 150 ml of water. Potassium carbonate is added, barium carbonate is filtered off with suction, and the filtrate is extracted ten times using 100 ml portions of chloroform. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. filtrationbarium carbonate is filtered off with suction
  2. extractionthe filtrate is extracted ten times
  3. dry with materialThe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-52b3a3bafcc645e28824fe18c7fcb92c
出典データセット
uspto-grants-1994_02
特許番号
US05284855

反応ノート

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