HCID 19100973、化合物 → HCID 19100943、化合物

HRID 1975028ノート

反応式

HRID 1975028 の反応式
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

参加物

3

反応物 1

HCID 19100973HCID 19100973、化合物

生成物 1

HCID 19100943HCID 19100943、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 100 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 20 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

後処理

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

出典と根拠

ORDレコード
ord-15f90691a1d34175a558224d4324b463
出典データセット
uspto-grants-1994_02
特許番号
US05284855

反応ノート

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