Ethanol → Benzeneacetic acid, 3,5-dibromo-4-hydroxy-, ethyl ester

HRID 1975257ノート

反応式

HRID 1975257 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([O:13][CH2:19][CH3:20])=[O:12])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3253142-(3,5-dibromo-4-hydroxyphenyl)acetic acid

生成物 1

HCID 318188Benzeneacetic acid, 3,5-dibromo-4-hydroxy-, ethyl ester

実験手順

3,5-Dibromo-4-hydroxyphenylacetic acid (60 g, 0.19 mol), from Preparation A, was suspended in 1 L of ethanol and 10 mL of concentrated sulfuric acid and heated at reflux overnight. The reaction mixture was cooled, concentrated and the product collected by filtration, washed with water, and dried in a vacuum oven to obtain ethyl 3,5-dibromo-4-hydroxyphenylacetate.

後処理

  1. temperatureat reflux overnight
  2. temperatureThe reaction mixture was cooled
  3. concentrationconcentrated
  4. filtrationthe product collected by filtration
  5. washwashed with water
  6. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-bddfa451827142e3b0ae96b43ddcd2e1
出典データセット
uspto-grants-1994_02
特許番号
US05284971

反応ノート

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