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o-Iodoanisole → Methyl 3,5-dibromo-4-(3-iodo-4-methoxyphenylthio)phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | o-Iodoanisole | HCID 68257 | — |
| 反応物 | 2-Isopropylanisole | HCID 270623 | — |
| 反応物 | Methyl 3,5-dibromo-4-mercaptophenylacetate | HCID 19101399 | — |
| 生成物 | Methyl 3,5-dibromo-4-(3-iodo-4-methoxyphenylthio)phenylacetate | HCID 19101415 | 83.2% |
反応手順
Following the procedures of Example 1, but substituting 2-iodoanisole for 2-isopropylanisole, methyl 3,5-dibromo-4-mercaptophenylacetate (1 g) was reacted with 2-iodoanisole (0.7 g) to yield the thioether, methyl 3,5-dibromo-4-(3-iodo-4-methoxyphenylthio)phenylacetate (1.4 g) which in turn was oxidized to methyl 3,5-dibromo-4-(3-iodo-4-methoxyphenylsulfonyl)phenylacetate, MP: 127°-129° C. The acetate was saponified to the acid, 3,5-dibromo-4-(3-iodo-4-methoxyphenylsulfonyl)phenylacetic acid, MP: 158°-162° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05284971 |
| 出典データセット | uspto-grants-1994_02 |
| ORD ID | ord-26ec20d2137d47b8a8041176bf5a81d9 |
| 出典メモ | uspto-grants-1994_02 |