Ammonia → 3,3-dicyclopropylpropanoic Acid
反応式
[OH-:1].[K+].[CH:3]1([CH:6]([CH:10]2[CH2:12][CH2:11]2)[CH2:7][C:8]#N)[CH2:5][CH2:4]1.N.Cl.[OH2:15]>C(O)COCCO>[CH:3]1([CH:6]([CH:10]2[CH2:12][CH2:11]2)[CH2:7][C:8]([OH:15])=[O:1])[CH2:5][CH2:4]1参加物
7
実験手順
45 g of potassium hydroxide are dissolved in 65 ml of water. 100 ml of diethylene glycol are added to the above solution followed by 30 g of the product obtained in stage A. The mixture is refluxed until the evolution of ammonia ceases. After cooling, 700 ml of water are added and the mixture is acidified with 12 N hydrochloric acid. After extraction with ether, the ethereal phases are pooled, washed with water until neutral, dried and evaporated. The expected product is obtained after distillation.
後処理
- temperatureAfter cooling
- extractionAfter extraction with ether
- washwashed with water until neutral,
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-5dd54d45d6654b718c3bf210f2e45843
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05286732
反応ノート
読み込み中…