Isopropanol → 1-Benzyl-3,4-dimethylpyridin-1-ium chloride

HRID 1975314ノート

反応式

HRID 1975314 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH3:7])=[C:3]([CH3:8])[CH:2]=1.[CH2:9]([Cl:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(O)(C)C>CCOCC>[Cl-:16].[C:10]1([CH2:9][N+:1]2[CH:6]=[CH:5][C:4]([CH3:7])=[C:3]([CH3:8])[CH:2]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 7503Benzyl ChlorideHCID 114173,4-Dimethylpyridine

生成物 1

HCID 139786171-Benzyl-3,4-dimethylpyridin-1-ium chloride収率 76.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 3,4-lutidine (112 mL, 1.0 mole), benzyl chloride (115 mL, 1.0 mole) and isopropanol (500 mL) was refluxed under nitrogen for 5 hours and then was stirred at room temperature for 60 hours. The mixture was diluted with ether and the resulting white precipitate was filtered and dried to afford 178.3 g (76%) of N-(phenylmethyl)-3,4-dimethylpyridinium chloride.

後処理

  1. temperaturewas refluxed under nitrogen for 5 hours
  2. filtrationthe resulting white precipitate was filtered
  3. customdried

出典と根拠

ORDレコード
ord-8031e33ee2264bb4aed4946663898cf8
出典データセット
uspto-grants-1994_02
特許番号
US05286733

反応ノート

読み込み中…