Carbon tetrabromide → 1-(3,5-Dimethylphenoxy)-2-bromopropane

HRID 1975538

反応式

HRID 1975538 の反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:21].[CH3:25][CH:26](O)[CH2:27][O:28][C:29]1[CH:34]=[C:33]([CH3:35])[CH:32]=[C:31]([CH3:36])[CH:30]=1>C(Cl)Cl>[CH3:36][C:31]1[CH:30]=[C:29]([CH:34]=[C:33]([CH3:35])[CH:32]=1)[O:28][CH2:27][CH:26]([Br:21])[CH3:25]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 110739942-Propanol, 1-(3,5-dimethylphenoxy)-

生成物 1

HCID 191002941-(3,5-Dimethylphenoxy)-2-bromopropane収率 74.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

0.94 Gram (3.6 mmol) of triphenylphosphine and 1.49 g (4.5 mmol) of carbon tetrabromide were added to a solution prepared by dissolving 0.54 g (3 mmol) of 1-methyl-2-(3,5-dimethylphenoxy)ethanol in 10 ml of methylene chloride, and the resultant mixture was stirred at room temperature for 30 minutes. After the reaction, the solid was separated by filtration, and the remaining methylene chloride solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=5:1 (v/v)) to give 0.54 g of 1-(3,5-dimethylphenoxy)-2-bromopropane (yield 74.7%).

後処理

  1. customprepared
  2. customAfter the reaction
  3. customthe solid was separated by filtration
  4. concentrationthe remaining methylene chloride solution was concentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=5:1 (v/v))

出典と根拠

ORDレコード
ord-619da100a3a84020af9a517059a1b0fc
出典データセット
uspto-grants-1994_02
特許番号
US05286905

関連ノート

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