Cyclopentyl isothiocyanate → N-[5-Chloro-3-(cyclopentylthiocarbamoyl)sulfamoylthiophen-2-yl]acetamide

HRID 1975927ノート

反応式

HRID 1975927 の反応式
[Cl:1][C:2]1[S:6][C:5]([NH:7][C:8](=[O:10])[CH3:9])=[C:4]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:3]=1.[CH:15]1([N:20]=[C:21]=[S:22])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[Cl:1][C:2]1[S:6][C:5]([NH:7][C:8](=[O:10])[CH3:9])=[C:4]([S:11](=[O:13])(=[O:14])[NH:12][C:21](=[S:22])[NH:20][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:3]=1

参加物

3

反応物 2

HCID 141792Cyclopentyl isothiocyanateHCID 22000000N-(5-chloro-3-sulfamoylthiophen-2-yl)-acetamide

生成物 1

HCID 21999997N-[5-Chloro-3-(cyclopentylthiocarbamoyl)sulfamoylthiophen-2-yl]acetamide

実験手順

The title compound was prepared from N-(5-chloro-3-sulfamoylthiophen-2-yl)-acetamide and cyclopentyl isothiocyanate by a procedure analogous to the procedure described in example 15a (yield of crude product: 93%); 1H-NMR (DMSO-d6): δ1.3-2.0 (m, 8H, (CH2)4), 2.28 (s, 3H, CH3), 4.32 (sext, 1H, CH), 7.16 (s, 1H, H-4), 8.48 (br d, 1H, NH), 10.23 (br s, 1H, NH).

出典と根拠

ORDレコード
ord-54ab9b7d65824b2a83913917efb5b319
出典データセット
uspto-grants-2001_05
特許番号
US06225310B1

反応ノート

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