Piperazine → 1-(3-Bromobenzenesulfonyl)piperazine

HRID 1976022ノート

反応式

HRID 1976022 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1>>[Br:7][C:8]1[CH:9]=[C:10]([S:14]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 4837PiperazineHCID 17943m-Bromobenzenesulphonyl chloride

生成物 1

HCID 24052531-(3-Bromobenzenesulfonyl)piperazine

実験手順

Using analogous procedures to those described in the portion of Example 58 which is concerned with the preparation of starting materials, piperazine was reacted with 3-bromophenylsulphonyl chloride to give 1-(3-bromophenylsulphonyl)piperazine which, in turn, was reacted with 3,5-dichlorophenylboronic acid to give 1-(3′,5′-dichlorobiphenyl-3-ylsulphonyl)piperazine in 29% yield;

出典と根拠

ORDレコード
ord-3b407b2ae1334481872cc7da50229682
出典データセット
uspto-grants-2001_05
特許番号
US06225309B1

反応ノート

読み込み中…