Dimethylamine → 3-bromo-N,N-dimethyl-5-(trifluoromethyl)pyridin-2-amine
反応式
Cl[C:2]1[C:7]([Br:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[CH3:13][NH:14][CH3:15]>>[Br:8][C:7]1[C:2]([N:14]([CH3:15])[CH3:13])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1参加物
3
実験手順
2-Chloro-3-bromo-5-trifluoromethylpyridine (509 mg, 1.95 mmol) was treated with ethanolic dimethylamine solution (10 ml) and heated at reflux for 2 hrs before being concentrated. The residue was partitioned between water (10 ml) and ethyl acetate (10 ml), and the organic phase washed with brine (10 ml) and dried (Na2SO4). The solution was then concentrated to give the product as a yellow oil (430 mg, 82% yield).
後処理
- temperatureheated
- temperatureat reflux for 2 hrs
- concentrationbefore being concentrated
- customThe residue was partitioned between water (10 ml) and ethyl acetate (10 ml)
- washthe organic phase washed with brine (10 ml)
- dry with materialdried (Na2SO4)
- concentrationThe solution was then concentrated
出典と根拠
- ORDレコード
- ord-e0b49f56cb46443fb2047f51ce983857
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06225320B1
反応ノート
読み込み中…