Benzyl Bromide → 2-Benzyloxy-3-bromo-5-trifluoromethylpyridine
反応式
[Br:1][C:2]1[C:3](=[O:12])[NH:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCCCCC.C(=O)([O-])[O-].[Ag+2]>[CH2:13]([O:12][C:3]1[C:2]([Br:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
5
実験手順
3-Bromo-5-trifluoromethyl-2(1H)-pyridone (6.09 g, 25.2 mmol) and silver carbonate (7.18 g, 26.0 mmol) were suspended in hexane (200 mL) and treated with benzyl bromide (6 mL, 50.3 mmol). The mixture was stirred for 18 hrs, then filtered. The filtrate was concentrated and the residue purified by silica chromatography to give the product as a white solid (7.65 g, 23 mmol, 91% yield).
後処理
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe residue purified by silica chromatography
出典と根拠
- ORDレコード
- ord-33da332533ff41c3a8792822a9d935af
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06225320B1
反応ノート
読み込み中…