Propylene Oxide → Cis-4-Hydroxy-D-Proline

HRID 1976229ノート

反応式

HRID 1976229 の反応式
Cl.[OH:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.C1OC1C>C(O)C>[OH:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1

参加物

4

反応物 2

HCID 6378Propylene OxideHCID 12310682(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

生成物 1

HCID 440014Cis-4-Hydroxy-D-Proline収率 85.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4.5 g of cis-4-hydroxy-D-proline hydrochloride in 300 ml of ethanol, there was added 13.1 g of propylene oxide at room temperature and then the mixture was heated under refluxing for one hour. After allowing the reaction liquid to cool, the crystals precipitated were filtered off, washed with ethanol and then dried to give 3.0 g (yield 85.4%) of the title compound.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder refluxing for one hour
  3. customthe reaction liquid
  4. temperatureto cool
  5. customthe crystals precipitated
  6. filtrationwere filtered off
  7. washwashed with ethanol
  8. customdried

出典と根拠

ORDレコード
ord-3f26763b80a24a19a92ac78a613c5999
出典データセット
uspto-grants-2001_05
特許番号
US06225306B1

反応ノート

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