4-Bromoanisole → HCID 21996968、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][C:12](C)=[CH:11][CH:10]=1)=[O:8].Br[C:20]1C=CC(OC)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]([CH3:20])[CH:14]=1)=[O:8]参加物
3
実験手順
Employing the same general procedure as for the preparation 5-bromo-2-methoxy-4′-methylbenzophenone (Compound H), 1.0 mL (1.5 g, 8.0 mmol) of 4-bromoanisole was converted into the title compound using 0.5 g (4.0 mmol) of aluminum chloride, 1.3 mL (1.5 g, 9.6 mmol) of m-toluoyl chloride and 20 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.
出典と根拠
- ORDレコード
- ord-2bf47a7153cf42989691be17ccc63506
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06225494B1
反応ノート
読み込み中…