HCID 21996968、化合物 → HCID 21996988、化合物

反応式

BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]

参加物

反応物 2

HCID 21996968HCID 21996968、化合物2 回

HCID 21996975HCID 21996975、化合物2 回

生成物 1

HCID 21996988HCID 21996988、化合物

実験手順

Employing the same general procedure as for the preparation 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 533 mg (1.7 mmol) of 5-bromo-2-methoxy-3′-methylbenzophenone (Compound J) was converted into the title compound using 2.6 mL (2.6 mmol) of boron tribromide (1M in dichloromethane) and 15 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.

出典と根拠

ORDレコード: ord-e0e682dfb3aa442bbeffb9f1fb04c9a9
出典データセット: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06225494B1

反応ノート

読み込み中…

参加物