3,4-Bis-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione → HCID 21999014、化合物
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[C:4]([C:14]2[C:15](=[O:33])[NH:16][C:17](=[O:32])[C:18]=2[C:19]2[C:27]3[C:22](=[CH:23][C:24]([N+:28]([O-])=O)=[CH:25][CH:26]=3)[N:21]([CH3:31])[CH:20]=2)=[CH:3]1>CN(C)C=O.[Ni]>[CH3:31][N:21]1[C:22]2[C:27](=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=2)[C:19]([C:18]2[C:17](=[O:32])[NH:16][C:15](=[O:33])[C:14]=2[C:4]2[C:5]3[C:10](=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)=[CH:20]1参加物
4
実験手順
3,4-Bis-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione (50 mg, 0.11 mmole), as prepared in Example 2 g, was dissolved in N,N-dimethylformamide (10 mL), a catalytic amount of activated Raney Nickel was added and the reaction was shaken on a Parr Hydro-genator at 45 psi. for 20 hr. The reaction mixture was filtered through a bed of celite with ethyl acetate and concentrated. The product was purified by recrystallization from acetone and hexane to give 3,4-bis-(1-methyl-6-amino-1H-indol-3-yl)-pyrrole-2,5-dione (35 mg).