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Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Chloro-1H-indole-5-carboxylic acid methyl ester | HCID 21998728 | 66.4% |
反応手順
A solution of methyl 5-indolecarboxylate (501.1 mg, 2.65 mmol) in methanol (15 mL) was treated with N-chlorosuccinimide (425.4 mg, 3.18 mmol), stirred for 18 hours, and concentrated. The concentrate was dissolved into ethyl acetate, and this solution was washed with 1M NaHCO3 (2×), dried (MgSO4), filtered, and concentrated. The concentrate was purified on silica gel with 15% ethyl acetate/hexanes to provide 368.8 mg of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06228868B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-932d88836c234f719928692ef1000938 |
| 出典メモ | uspto-grants-2001_05 |