1-Bromodecane → Methyl 1-decylpyrazole-4-carboxylate

HRID 1977272ノート

反応式

HRID 1977272 の反応式
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].C(OCC)(=O)C>CN(C)C=O>[CH2:17]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

6

反応物 4

HCID 81731-BromodecaneHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 9793760Methyl 1H-pyrazole-4-carboxylate

生成物 1

HCID 21997475Methyl 1-decylpyrazole-4-carboxylate収率 91.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of methyl pyrazole-4-carboxylate (10 g) in N,N-dimethylformamide (100 ml) was treated with potassium carbonate (10.95 g) and 1-bromodecane (19.31 g) and the mixture was stirred for 16 hours at room temperature. Ethyl acetate was added and the solution was washed with water (6x), dried over magnesium sulfate and the evaporated residue was purified by silica gel chromatography (5:1 hexane-ethyl acetate elution) to give methyl 1-decylpyrazole-4-carboxylate (19.4 g) as a white solid.

後処理

  1. washthe solution was washed with water (6x)
  2. dry with materialdried over magnesium sulfate
  3. customthe evaporated residue was purified by silica gel chromatography (5:1 hexane-ethyl acetate elution)

出典と根拠

ORDレコード
ord-f0658be6345648c9a1efd316d7a6c00f
出典データセット
uspto-grants-2001_05
特許番号
US06232290B1

反応ノート

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