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Triethylamine → 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 反応物 | 5-Nitro-isophthalic acid 1-(2,5-dioxo-pyrrolidin-1-yl) ester 3-allyl ester | HCID 22986099 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester | HCID 20655861 | — |
反応手順
A mixture of (7(b)) (2.00 g), N,O-dimethylhydroxylamine hydrochloride (0.62 g), triethylamine (0.86 ml) and dichloromethane (60 ml) was stirred at 5° for 30 min and then allowed to warm to ambient temperature and stirred for a further 16 h. The mixture was poured onto a flash column and eluted with ethyl acetate/hexane (40:60)to give 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester (7(c)) as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06232338B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-fa852f342c674df3a82b19d74e6f6a87 |
| 出典メモ | uspto-grants-2001_05 |