Glyoxylic Acid → 58207-08-2

HRID 1977491ノート

反応式

HRID 1977491 の反応式
[C:1]([OH:5])(=[O:4])[CH:2]=O.C([N:15](CC1C=CC(OC)=CC=1)C)C1C=CC(OC)=CC=1.[C:26]1([CH:32]=[CH:33]B(O)O)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C1(C)C=CC=CC=1>[NH2:15][CH:2](/[CH:33]=[CH:32]/[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:1]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 760Glyoxylic AcidHCID 27343812-Phenylvinylboronic acidHCID 19866082HCID 19866082、化合物

生成物 1

HCID 588530958207-08-2収率 202.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred solution of glyoxylic acid (110 mg, 1.2 mmol) in toluene (12 mL) was added di-(p-anisyl)-methylamine (291 mg, 1.2 mmol) in one portion. After 1 min, 2-phenylethenyl boronic acid (177 mg, 1.2 mmol) was added and the reaction mixture was stirred vigorously for 12 hours. The precipitated product was isolated by filtration, washed with dichloromethane (15 mL), toluene (10 mL) and dried under vacuum to give the expected product (430 mg, 89% yield). 1H-NMR (360 MHz, CD3OH) d 6.8-7.5 (m, 13H), 6.60 (d, J=15.5 Hz, 1H), 6.25 (dd, J=15.5 Hz, 9.5 Hz, 1H), 5.49 (s, 1H), 4.00 (d, J=9.5 Hz, 1H), 3.75 (s, 6H), 2.3 (s, 1H).

後処理

  1. customThe precipitated product was isolated by filtration
  2. washwashed with dichloromethane (15 mL), toluene (10 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-0bfb312c17aa449aa1541e20b4aa9604
出典データセット
uspto-grants-2001_05
特許番号
US06232467B1

反応ノート

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