Acetone → (E)-6-Methyl-3-hepten-2-one

HRID 1977522ノート

反応式

HRID 1977522 の反応式
[CH:1](=O)[CH2:2][CH:3]([CH3:5])[CH3:4].[CH3:7][C:8]([CH3:10])=[O:9]>>[CH3:4][CH:3]([CH3:5])[CH2:2][CH:1]=[CH:7][C:8](=[O:9])[CH3:10]

参加物

3

反応物 2

HCID 180AcetoneHCID 115523-Methylbutanal

生成物 1

HCID 137281(E)-6-Methyl-3-hepten-2-one収率 35%

実験手順

In contrast, the processes comprising subjecting isovaleraldehyde and acetone to aldol condensation in the presence of an aqueous alkali have an advantage that the reaction can be carried out under mild conditions, using inexpensive materials. The process (iv), however, can give 6-methyl-3-hepten-2-one, the aldol condensate, only in a 35 to 40% yield at most. Also, the process (v) mainly forms 6-methyl-4-hydroxyheptan-2-one, and requires successive dehydration reaction in order to obtain the yield of the 6-methyl-3-hepten-2-one. In addition, the yield of the 6-methyl-3-hepten-2-one thus obtained is 51%, which is not satisfactory. Moreover, the process (v) must use acetone in excess, so it is not industrially advantageous in view of the necessity for recovering the excessive acetone and the volumetric efficiency of reaction.

後処理

  1. customcondensation in the presence of an aqueous alkali
  2. customthat the reaction

出典と根拠

ORDレコード
ord-7fb56c40ff7c466eafa358bddcf55fad
出典データセット
uspto-grants-2001_05
特許番号
US06232506B1

反応ノート

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