2,3-Dimethylaniline → 6-Chloro-2,3-dimethylaniline

HRID 1977649

反応式

HRID 1977649 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>CN(C=O)C>[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]([Cl:1])[C:11]=1[NH2:12]

参加物

4

反応物 2

HCID 68932,3-DimethylanilineHCID 31398Chlorosuccinimide

生成物 1

HCID 219947436-Chloro-2,3-dimethylaniline収率 99%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

used in the preparation of 389 was prepared as follows: N-Chlorosuccinimide (1.00 g; 8.2 mmol) was added to a solution of 2,3-dimethylaniline (1 ml; 8.2 mmol) in 20 ml of DMF in the dark. After stirring 1 hr. in the dark, the reaction mixture was partitioned between EtOAc (100 ml) and water (100 ml). The organic layer was washed with 1N NaOH (100 ml), water (100 ml) and brine (50 ml). Drying (MgSO4) and concentration afforded 1.25 g (99%) of 2,3-dimethyl-6-chloroaniline as a deep red liquid.

後処理

  1. customwas prepared
  2. customin the dark, the reaction mixture was partitioned between EtOAc (100 ml) and water (100 ml)
  3. washThe organic layer was washed with 1N NaOH (100 ml), water (100 ml) and brine (50 ml)
  4. customDrying
  5. concentration(MgSO4) and concentration

出典と根拠

ORDレコード
ord-b0cb638d6a32473e867ac1465c30ef9d
出典データセット
uspto-grants-2001_05
特許番号
US06235740B1

関連ノート

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