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2-Bromopyridine → 2-fluoro-N-(2-pyridyl)acetanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromopyridine | HCID 7973 | — |
| 反応物 | 2-Fluoro-N-phenylacetamide | HCID 9504 | — |
| 生成物 | 2-fluoro-N-(2-pyridyl)acetanilide | HCID 21993511 | 75.2% |
反応手順
Using 2-fluoroacetanilide (4.6 g) and 2-bromopyridine (9.5 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1.5) produced 2-fluoro-N-(2-pyridyl)acetanilide (5.2 g, crude product) as a red oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06235730B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-742831b86bf34a6ca0b650a7d420922f |
| 出典メモ | uspto-grants-2001_05 |