Hydrochloric Acid → 2-(Piperidin-4-yl)benzonitrile hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=2[C:16]#[N:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=2[C:16]#[N:17])[CH2:10][CH2:9]1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of 2-(1-tertbutoxycarbonylpiperidin-4-yl)benzonitrile (1.7 g, 5.9 mmol) in ethyl acetate (˜50 ml), cooled to 0° C. was added hydrogen chloride gas, bubbled vigorously for 5 minutes. The reaction mixture was stirred for 10 minutes at 0° C., purged with argon and concentrated. Flushing with ethyl acetate×3 and concentration gave 2-(piperidin-4-yl) benzonitrile hydrochloride.
後処理
- custombubbled vigorously for 5 minutes
- custompurged with argon
- concentrationconcentrated
- customFlushing with ethyl acetate×3 and concentration
出典と根拠
- ORDレコード
- ord-e5c3211e59ad4b079c4a38205ab9cf6e
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06235759B1
反応ノート
読み込み中…