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HRID 1978026作成日：2026年10月27日
3-Benzyl-1-(4'-methoxybenzyl)-2,5-dioxo-4,4-dimethylimidazolidine → 3-Benzyl-2,5-dioxo-4,4-dimethylimidazolidine
https://huagongshe.com/reaction/1978026
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Benzyl-1-(4'-methoxybenzyl)-2,5-dioxo-4,4-dimethylimidazolidine | HCID 21700023 | — |
| 反応物 | Ammonium cerium-nitrate | HCID 57418452 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-Benzyl-2,5-dioxo-4,4-dimethylimidazolidine | HCID 4601988 | 63% |
反応手順
A solution of 3-benzyl-1-(4′-methoxybenzyl)-2,5-dioxo-4,4-dimethylimidazolidine (3.9 g, 11.54 mmol) in acetonitrile (100 mL) was treated with a solution of ammonium cerium nitrate (31 g, 57.7 mmol) in 65 mL of water, stirred at 25° C. for 15 minutes, then diluted with ethyl acetate and partitioned between ethyl acetate and brine. The organic layer was dried, filtered, and concentrated. Purification by recrystalization with ethyl acetate/hexane provided 1.58 g (7.25 mmol, 63%) of the desired product as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06235786B1 |
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| 出典データセット | uspto-grants-2001_05 |
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| ORD ID | ord-fae5a3e119b24dd999adacb62565b9ba |
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| 出典メモ | uspto-grants-2001_05 |
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