Trifluoroacetic anhydride → HCID 22880382、化合物

HRID 1978087ノート

反応式

HRID 1978087 の反応式
[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([OH:8])=[O:7])([OH:3])=[O:2].F[C:15](F)(F)C(OC(=O)C(F)(F)F)=O>>[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([O:8][CH3:15])=[O:7])([OH:3])=[O:2]

参加物

3

反応物 2

HCID 9845Trifluoroacetic anhydrideHCID 10845347Disodium (2S,3R)-2-hydroxy-3-isobutylsuccinate

生成物 1

HCID 22880382HCID 22880382、化合物

実験手順

4.48 g of 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoic acid were stirred under nitrogen in 10 ml of trifluoroacetic anhydride for 1.5 hours. The solvent was evaporated and the residue was dissolved in 20 ml of dry methanol and stirred overnight at room temperature. The solvent was evaporated to give 5.3 g of methyl 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoate in the form of an orange oil.

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in 20 ml of dry methanol
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-6efa1773777f44bab4707db4573dc354
出典データセット
uspto-grants-2001_05
特許番号
US06235787B1

反応ノート

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