Ammonia → 3-Methoxy-5-methylpyrazine-2-carboxamide

HRID 1978141ノート

反応式

HRID 1978141 の反応式
[CH3:1][O:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1.[NH3:14]>>[CH3:1][O:2][C:3]1[C:4]([C:10]([NH2:14])=[O:12])=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 21702987Methyl 3-methoxy-5-methylpyrazine-2-carboxylate

生成物 1

HCID 110627763-Methoxy-5-methylpyrazine-2-carboxamide収率 87%

実験手順

1 g (5.5 mmol) of methyl 3-methoxy-5-methylpyrazine-carboxylate was initially charged in 15 ml (198 mmol) of NH3 (25%) and the mixture was stied at 50° C. After concentration, 0.8 g of 3-methoxy-5-methylpyrazine-2carboxamide was obtained. The yield was 86 percent. Other data concerning the title product was:

後処理

  1. customwas stied at 50° C
  2. concentrationAfter concentration

出典と根拠

ORDレコード
ord-5ae1cef7b8154ee1815fb4d0c6ec7b33
出典データセット
uspto-grants-2001_05
特許番号
US06235905B1

反応ノート

読み込み中…