化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl cyanoacetate → Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl cyanoacetate | HCID 7764 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Perfluoropropionyl chloride | HCID 67911 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate | HCID 86756713 | — |
反応手順
To 20 ml of tetrahydrofuran, 3.39 g (30 mmol) of ethyl cyanoacetate and 6.06 g (60 mmol) of triethylamine were dissolved and stirred at room temperature. Successively, 5.47 g (30 mmol) of pentafluoropropionyl chloride was dropwise added and stirred for 5 hours at room temperature. However, formation of desired product could not be confirmed.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06235911B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-5ebf959e1e1d4832bd243770b69d9c26 |
| 出典メモ | uspto-grants-2001_05 |