HCID 21996975、化合物 → HCID 21996970、化合物
反応式
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=1)=[O:25]>>[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=1)=[O:25]参加物
3
実験手順
Employing the same general procedure as for the 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 319 mg (1.0 mmol) of 5-bromo-2-methoxy-4-methyl-4′-methylbenzophenone (Compound I) was converted into the title compound using 2.4 mL (2.4 mmol) of boron tribromide (1M in dichloromethane) and 10 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a pale yellow solid.
出典と根拠
- ORDレコード
- ord-6de7745f09114e20bd712769e7e53a65
- 出典データセット
- uspto-grants-2001_05
- 特許番号