Formamide → HCID 21994064、化合物

HRID 1978384ノート

反応式

HRID 1978384 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[N:3]=1.O.C(OCC)(=O)C.[CH:16]([NH2:18])=[O:17]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:18][CH:16]=[O:17])[N:3]=1

参加物

5

反応物 4

HCID 713FormamideHCID 962WaterHCID 8857Ethyl AcetateHCID 739342,6-Difluoropyridine

生成物 1

HCID 21994064HCID 21994064、化合物

実験手順

A solution of 0.63 g of 2,6-difluoropyridine in 0.2 mL of formamide was stirred for 3 hours at 150° C. The reaction mixture was cooled to room temperature, to which were added water (100 mL) and ethyl acetate (100 mL×3) for extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to give powdery precipitate of 2-fluoro-6-(formylamino)pyridine. The powdery product was collected by filtration and dried for 2 hours at 40° C. under reduced pressure (0.4 g).

後処理

  1. extractionfor extraction
  2. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
  3. concentrationfollowed by concentration

出典と根拠

ORDレコード
ord-a4c247602d1c4bc3bae2c1adc436f19b
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

反応ノート

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