Hydrochloride methanol → n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978464

反応式

HRID 1978464 の反応式
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:32].CO>C(O)C>[ClH:32].[ClH:32].[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 21993902N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

生成物 1

HCID 21993901n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 414 mg (0.95 mM) of N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (9 ml) was added 1.0 ml (4 mM) of 4N-HCl/methanol and the mixture was stirred at room temperature for 30 minutes. The resulting crystals were collected by filtration and rinsed with ethanol and ether to provide the title compound.

後処理

  1. filtrationThe resulting crystals were collected by filtration
  2. washrinsed with ethanol and ether

出典と根拠

ORDレコード
ord-2ae5c4ed864d4d1690729d5a8fd1e0a6
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

関連ノート

読み込み中…